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KMID : 0370220120560030198
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Yakhak Hoeji
2012 Volume.56 No. 3 p.198 ~ p.203
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Effect of Chrysin on Tumor Necrosis Factor--induced Mucin Production, Mucin Gene Expression and Translocation of Nuclear Factor-kappa B in Cultured Airway Epithelial Cells
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Shin Hyun-Dae
Lee Hyun-Jae
Md. Asaduzzaman Sikder
Ryu Ji-Ho
Park Soo-Hyun
Hong Jang-Hee
Seok Jeong-Ho
Lee Choong-Jae
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Abstract
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Chrysin and chlorogenic acid are natural products derived from Scutellariae Radix and Lonicerae Flos, respectively. We examined whether chrysin and chlorogenic acid affect airway mucin production induced by TNF- in NCI-H292 cells. Cells were pretreated with each agent for 30 min and then stimulated with TNF- for 24 h. Of the two compounds, chrysin suppressed airway MUC5AC mucin production. Also, chrysin suppressed MUC5AC mucin gene expression and translocation of NF- p65 induced by TNF-. This result suggests that chrysin can regulate the production and gene expression of mucin induced by TNF- through the inactivation of NF- in airway epithelial cells.
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KEYWORD
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airway, mucin, chrysin
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